Description

INTRODUCTION 

Pramiracetam is one of the most interesting nootropics available, offering the greatest potency of
any of the racetam-class supplements. Its unique action optimizes overall brain function, improving
memory, learning capacity, focus, and even sensory perception. It works well on its own and can be
an invaluable addition to other nootropics, enhancing and extending their effects.
Pramiracetam is a synthetic derivative of piracetam, discovered and developed by Parke-Davis in
the 1970s. It is a particularly potent supplement, estimated to be from 5-30x more potent than
piracetam.
It was patented in the US in 1979 but is not approved by the USFDA for any particular use.
However, it has been extensively studied as a potential treatment for cognitive problems and
memory loss associated with Alzheimer’s disease and brain injury. It has also been studied as a
treatment for a variety of central nervous system disorders.

BENEFITS

Pramiracetam optimizes brain performance and provides marked cognitive improvement,
particularly regarding memory formation and retrieval.
Because it often creates a noticeable feeling of focus along with a certain amount of emotional
blunting, it is often compared to Ritalin. Some of the most widely-recognized benefits of
pramiracetam are as follows:
Improved Memory – Because it stimulates the hippocampus, the part of the brain primarily
responsible for the creation of new memories, pramiracetam is known as a very powerful memory
enhancer. Most users report significant improvement in memory formation and speed of recall, a
claim that has been corroborated by animal studies.
Expanded Learning Capacity – Users report that pramiracetam makes learning faster, easier, and
more enjoyable. This can be explained at least in part by pramiracetam’s facilitation of greater
neuroplasticity.
Mental Alertness and Clarity – Typically users report that taking pramiracetam gives them strong
feelings of mental alertness, focus, rapid idea formation, and clear thinking.
Social Fluency – Many users say that taking pramiracetam helps them enjoy and fully participate in
social situations, a benefit that is likely related to the supplement’s overall brain function
optimization but could also be somewhat related to its emotional blunting effects, which may
reduce social anxiety.
Improved Sensory Perception – Users often report enhanced or improved sensory perceptions,
including amplified and richer sound and clearer and more vivid visual perception with greater
color contrast.
Memory Repair – In limited clinical trials, pramiracetam has been shown to be an effective
treatment for memory loss and other cognitive problems caused by brain injuries. It is also one of
the various nootropics that have been tested in the US as a possible treatment of memory loss
related to Alzheimer’s disease and other neurological disorders. One study has even shown it to be
capable of reversing chemically induced amnesia in healthy volunteers from 18-65 years of age.

RESEARCH DOSAGE

Though Pramiracetam is well tolerated even at high dosages, individual reactions vary and it’s
important for each user to find their own optimal dosage to maximize benefits.
Due to the lack of sufficient scientific studies, recommendations on the most effective daily dose
vary considerably. Of the various studies done on testing the effectiveness of Pramiracetam, they
concluded that a total daily intake of 1200 mg divided into two or three doses was optimal.
This is likely a good starting point and on an individual level should be adjusted to find what works
best for you.

While there are very few adverse side effects associated with this supplement, it is always wise to
start with the lowest effective dose and increase the dose gradually as needed.

Pramiracetam is fat rather than water soluble – that means that mixing the powder with water is difficult.
Rather than dissolving, it will simply float on the surface. Some users report dissolving their dose of
pramiracetam powder with a small amount of oil which may also enhance absorption and
bioavailability.

SIDE EFFECTS

Pramiracetam is usually well tolerated even at high dosages, and very few adverse side effects have
been documented.
The most commonly reported side effect is a headache, which can usually be prevented by taking it
with a choline supplement.
Less common side effects, including gastrointestinal distress and feelings of nervousness or
agitation, are generally associated with high dosage and can, therefore, be avoided by reducing
dosage.
Pramiracetam is non-addictive, and no significant adverse effects of long-term use have been
documented. In fact, there is evidence that this supplement may even promote brain health and to
some extent restore function in aging brains.

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