€21.90 – €59.90
Daniel Barulli, PhD (Psychology), last updated: September 19, 2019. “7 Potential Uses of Picamilon + Dosage & Side Effects”. Retrieved from https://selfhacked.com/blog/picamilon/.
Picamilon (N-nicotinoyl-GABA) is a synthetic combination of GABA and Niacin (vitamin B3) used in the treatment of anxiety disorders.
GABA is a neurotransmitter with relaxing and anti-anxiety effects.
Niacin is a vitamin involved in DNA repair, fat and cholesterol synthesis, and widening of blood vessels.
When taken as an oral supplement by itself GABA is not able to cross the blood-brain barrier (only a small amount does). However, Picamilon (GABA bound to Niacin) is able to cross the blood-brain barrier.
Once in the brain, GABA activates GABA (both GABA-A and GABA-B) receptors, while Niacin increases blood flow to the brain by dilating blood vessels. This additional blood flow to the brain is thought to provide the neuroprotective and nootropic benefits of Picamilon. New blood coming into the brain brings fresh oxygen and other essential nutrients that nourish brain cells.
GABA is the brain’s primary inhibitory neurotransmitter, and greater levels of this molecule are associated with decreased levels of anxiety.
When released, GABA slows the firing rate of neurons. Too much Glutamate can contribute to feelings of anxiety, muscular tension, and even increased the risk of seizures. GABA slows neuronal firing rates by blocking the activity of Glutamate, the brain’s primary excitatory neurotransmitter.
GABA’s main role in the brain is to slow down excitatory communication between neurons. Too little GABA can cause restless thinking, anxiety, and insomnia. Increasing GABA in the brain alleviates all of these symptoms.
People with excessively low levels of GABA tend to develop anxiety disorders, suggesting that increasing GABA could provide an effective treatment for anxiety.
Picamilon reversed both anxiety and depression and activated GABA receptors in rats.